Anaphase human cell
stained for microtubules (green) and DNA (purple).
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3D Actin
3D reconstructions of actin filaments decorated with Myosin V.
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Human cell depleted of kinesin-like motors
Kinetochores (green) and centrosomes (red) in a human cell depleted of the kinesin-like motors Kif18A and Kid.
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Intracellular Cargo Transport
Myosin V carries intracellular cargo by taking numerous ~36 nm processive steps along its actin track.chat18.webcam
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Native cardiac thick filaments and cMyBP-C
(A) Cardiac muscle sarcomere with interdigitating thick and thin filaments
(B) One half of thick filament with an actin filament ...
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(B) One half of thick filament with an actin filament ...
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A metaphase human cell expressing a kinesin-like motor
Motor: GFP-Kif18B (green) stained for EB1 (red) and DNA (blue).
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Smooth Muscle Actin
A study on the functional effect of mutation in smooth muscle actin implicated in inherited vascular diseases.
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Native Thick Filaments from Drosophila
Bar zones and star shaped filament bundles from drosophila, imaged with an AFM.
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At the bench
We are engaged in cutting edge investigations of molecular physiology using biophysical techniques.
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