Molecular Physiology & Biophysics at the University of Vermont

Anaphase human cell

stained for microtubules (green) and DNA (purple).
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3D Actin

3D reconstructions of actin filaments decorated with Myosin V.
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Human cell depleted of kinesin-like motors

Kinetochores (green) and centrosomes (red) in a human cell depleted of the kinesin-like motors Kif18A and Kid.
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Intracellular Cargo Transport

Myosin V carries intracellular cargo by taking numerous ~36 nm processive steps along its actin track.
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HSRF

The Health Sciences Research Facility houses the majority of our department's labs. Additional labs are located in the adjacent Given building.

Native cardiac thick filaments and cMyBP-C

(A) Cardiac muscle sarcomere with interdigitating thick and thin filaments
(B) One half of thick filament with an actin filament ...
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A metaphase human cell expressing a kinesin-like motor

Motor: GFP-Kif18B (green) stained for EB1 (red) and DNA (blue).
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Smooth Muscle Actin

A study on the functional effect of mutation in smooth muscle actin implicated in inherited vascular diseases.
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Native Thick Filaments from Drosophila

Bar zones and star shaped filament bundles from drosophila, imaged with an AFM.
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At the bench

We are engaged in cutting edge investigations of molecular physiology using biophysical techniques.
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Graduate Studies

Students join established research programs centered around cardiovascular physiology, structure/function studies of proteins and macromolecular complexes. Learn more....

Our work focuses on protein structure and function with emphasis on contractile and cytoskeletal proteins, as well as an existing expertise in molecular biology, single molecule biophysics, and structural biology. Learn more...