Dr Hailong Lu received his Ph. D in Biophysical Chemistry at University of New Mexico in 2004, and continued his research on molecular motor protein as a post-doctoral associate at The University of Vermont. In 2010, Dr. Lu joined the faculty as a Research Associate.
I am interested in molecular motor proteins and the mechanism of their activity, interaction and regulation, both as individual motor and working as a group. The goal is to fully understand their functions for normal functioning of the cell. We use various biophysical and biochemical techniques to study the property of purified myosin V and kinesin. We also use live cell imaging to study the behavior of molecular motors in their native environments. Combining the finding from in vivo and in vitro approaches, I hope we can have a better understanding of molecular motor proteins.
Faculty Highlighted Publications
Lu H, Krementsova EB, Trybus KM. Regulation of Myosin V Processivity by Calcium at the Single Molecule Level. J. Biol. Chem. 2006 Oct; 281: 31987-31994
Lu H, Ali MY, Bookwalter CS, Warshaw DM, Trybus KM. Diffusive movement of processive kinesin-1 on microtubules. Traffic. 2009 Oct; 10: 1429-38
Lu H, Efremov AK, Bookwalter CS, Krementsova EB, , Driver EB, Trybus KM, and Diehl MR. Collective Dynamics of Elastically Coupled Myosin V Motors. J. Biol. Chem. 2012 287: 27753-27761.
Lu H, Kennedy GG, Warshaw DM, Trybus, KM. Simultaneous Observation of Tail and Head Movements of Myosin V during Processive Motion. J. Biol. Chem., 2010 Dec; 285: 42068-42074
Ali MY, Lu H, Bookwalter CS, Warshaw DM, Trybus KM. Myosin V and Kinesin act as tethers to enhance each others' processivity. PNAS. 2008 Mar; 105: 4691-4696