M. Radermacher,Dreidimesionale Rekonstruktion bei kegelförmiger Kippung im Elektronenmikroskop. Technische Universität München, 1980, Germany; pdf

Articles and book chapters

D. Typke, M. Radermacher, Determination of the Phase of Complex Atomic Scattering Amplitudes from Light Optical Diffractograms of Electron Microscope Images. Ultramicroscopy, 9, (1982), 131-138

W. Hoppe, W. Kerzendorf, R. Guckenberger, R. Hegerl, V. Knauer, G. Nützel, M. Radermacher, D. Typke, Schritte zur Automatisierung der Datenerfassung für die dreidimensionale Rekonstruktion aus  elektronenmikroskopischen Bildern. Fresenius Z. Anal. Chem. 312, (1982), 27-28

J.A. Subirana, S. Munoz-Guerra, M. Radermacher,  J. Frank, Three-Dimensional Reconstruction of Chromatin Fibers, J.Biomol. Stereodynamics, I, (1983), 705-714

J.A. Subirana, S. Munoz-Guerra, J. Aymami, M. Radermacher, J. Frank Chromatin Fibers Reconstructed in 3 Dimensions J.Cell Biology 97, (1983) 391A

A. Verschoor, J. Frank, M. Radermacher, T. Wagenknecht, M. Boublik Three-dimensional reconstruction of the 30s ribosomal Subunit from Randomly Oriented Particles. J. Mol.Biol. (1984) 178, 677-698

M. Radermacher, J. Frank, Representation of Three-Dimensional Reconstructed Objects in Electron Microscopy by Surfaces of Equal Density, J.Microscopy, 136, (1984), 77-85

M. Kessel, M. Radermacher, J. Frank, The Structure of the Stalk Surface Layer of a Brine Pond Microorganism: Correlation Averaging Applied to a Double Layered Lattice Structure. Journal of Microscopy, 139, (1985), 63-74

C.H. Kim, M. Radermacher, M. Kessel, J. Frank, T.E. King, Three-dimensional Reconstruction of Cytochrome Oxidase Vesicle Crystals Prepared by Cholate Solubilization. Journal of Anorganic Biochemistry, 23, (1985) 163-169

J.A. Subirana, S. Munoz Guerra, J. Aymami,  M. Radermacher, J. Frank, The Layered Organization Of Nucleosomes In 30 Nanometer Chromatin Fibers. Chromosoma (Berlin) 91 (1985) 377-390.

D.F. Parsons, M. Marko, M.  Radermacher , J. Frank Shape Changes And Polarization Of Cell Migrating Through Tissue A High-Voltage Electron Microscope And Computer Graphics Study Of Serial Thick Sections. Tissue & Cell 17 (1985) 491-510.

M. Radermacher, J. Frank, Use of Nonlinear Mapping in Multivariate Image analysis of Molecule Projections. Ultramicroscopy, 17, (1985), 117-126

M. Radermacher, T. Wagenknecht, A. Verschoor, J. Frank, A new 3-D reconstruction scheme applied to the 50S ribosomal subunit of E.coli. J. Microsc. 141 1986 RP1-RP2

J. Frank, M. Radermacher, T. Wagenknecht, A. Verschoor, A new method for three-dimensional reconstruction of single macromolecules using low-dose electron micrographs. Ann. N.Y. Acad. Sci. 483, (1987), 77-87

B.F. McEwen, M. Radermacher, C.L. Rieder, J. Frank, Tomographic three-dimensional reconstruction of cilia ultrastructure from thick sections. Proc. Natl. Acad. Sci., USA, 83 (1986) 9040-9044.

M. Boublik, G.T. Oostergetel, J.S. Wall, J.F. Hainfield, M. Radermacher, T. Wagenknecht, A. Verschoor, J. Frank, Structure of ribosomes and their components by advanced techniques of electron microscopy and computer image analysis. in “Structure, Function, and Genetics of Ribosomes” (ed. B.Hardesty, G.Kramer), Springer Verlag Heidelberg, 1986

J. Frank, M. Radermacher, Three-dimensional reconstruction of nonperiodic macromolecular assemblies from electron micrographs, in “Advanced Techniques in Biological Electron Microscopy III” (ed. J.Koehler), Springer Verlag Heidelberg, 1986

M. Radermacher, T. Wagenknecht, A. Verschoor, J. Frank, Three-dimensional reconstruction from a single-exposure random conical tilt series applied to the 50S ribosomal subunit of Escherichia coli. J. Microsc. 146, (1987), 113-136

J. Frank, B.F. McEwen, M. Radermacher, J.N. Turner, C.L. Rieder, Three-dimensional tomographic reconstruction in high voltage electron microscopy. Journal of El. Micr. Techniques 6 (1987), 193-205.

M. Radermacher, T. Wagenknecht, A. Verschoor, J. Frank, Three-dimensional structure of the large subunit from Escherichia coli. EMBO J. 6, (1987), 1107-1114

J. Frank, A. Verschoor, T. Wagenknecht, M. Radermacher, J.M. Carazo  A new non-crystallographic image-processing technique reveals the architecture of ribosomes. Trends in Biochem. Sci. 13, (1988), 123-127

J.M. Carazo, T. Wagenknecht, M. Radermacher, V. Mandiyan, M. Boublik, J. Frank. Three-dimensional structure of 50S Escherichia coli ribosomal subunits depleted of proteins L7/L12. J. Mol. Biol. 201, (1988), 393-404

A. Saito, M. Inui, M. Radermacher, J. Frank, S. Fleischer Ultrastructure of the Calcium Release Channel of Sarcoplasmic Reticulum. J. Cell Biol. 107, 1988, 211-219

J. Frank, M. Radermacher, T. Wagenknecht ,A. Verschoor. Studying the ribosome structure by electron microscopy and computer image processing. in Methods in Enzymology, Vol 164, Ribosomes, (ed. H.F.Noller, Jr. and K.Moldave) Academic Press, 1988

M. Radermacher, Three-dimensional reconstruction of single particles from random and nonrandom tilt series. J. Electr. Micr. Technique 9, (1988), 359-394

T. Wagenknecht, J.-M. Carazo, M. Radermacher, J. Frank Three-dimensional reconstruction of the Ribosome from Escherichia coli. Biophysical J. 55, 1989, 455-464

A.Verschoor, N.-Y. Zhang, T. Wagenknecht, T. Obrig, M. Radermacher, J. Frank, Three-dimensional reconstruction of mammalian 40S ribosomal subunit. J.Mol.Biol. 209, 1989,115-126

J.M. Carazo, F.F. Rivera, E.L. Zapata, M. Radermacher,  J. Frank, Fuzzy sets-based classification  of electron microscopy images of biological macromolecules with an application to ribosomal particles. Journ. Microscopy, 157, 1990, 187-203

J. Frank., A. Verschoor, M. Radermacher, T. Wagenknecht, Morphologies of eubacterial and eucariotic ribosomes as determined by three-dimensional electron microscopy. in:W.E. Hill, P.B.Moore  A.Dahlberg, D.Schlessinger, R.A.Garrett, J.R.Warner eds. The  Ribosome, Structure Function and Evolution. American Society for Microbiology, Washington D.C., 1990, 107-113

N. Boisset, J.-C. Taveau, J. Lamy, T. Wagenknecht, M. Radermacher, J. Frank, Three-dimensional reconstruction of native androctonus australis hemocyanin. J.Mol.Biol,216,1990,743-760.

M. Radermacher, Three-dimensional Reconstruction of Single Particles. in “Image Analysis in Biology”, (ed. D.P. Häder) CRC Press inc., Bocca Raton 1991, chapter 12,  219-249.

M. Radermacher, T. Wagenknecht, R. Grassucci, J. Frank, M. Inui, C. Chadwick, S. Fleischer. Cryo-EM of the native Structure of the Calcium Release Channel/Ryanodine Receptor from Sarcoplasmic Reticulum. Biophysical Journal, 61, 1992, 936-940.

P. Penczek, M. Radermacher, J. Frank. Three-dimensional reconstruction of single particles embedded in ice. Ultramicroscopy, 40,1992, 33-53

J. Frank, M. Radermacher, Three-dimensional reconstruction of single particles negatively  stained or in vitreous ice. Ultramicroscopy 46,1992, 241-262.

M. Radermacher, Weighted Back-projection Methods. In: “Electron Tomography” (ed. J.Frank), Plenum Press, New York, 1992, pp.91-115

C.W. Akey, M. Radermacher, Architecture of the Xenopus Nuclear Pore Complex Revealed by 3-Dimensional Cryo-Electron Microscopy. J. Cell Biol.122, 1993, 1-9.

A. Verschoor, S. Srivastava, M. Radermacher, J. Frank, R. Traut, M. Stöffler-Meilicke, D. Glitz, Functional site determination in three dimensions on eukariotic and eubacterial ribosomes. in: The Translational Apparatus, (ed.:K.Nierhaus, F.Franceschi, A.R.Subramanian, V.Erdmann, B. Wittmann-Liebold) Plenum Press 1993, 411-419

N. Boisset, M. Radermacher, R. Grassucci,J.-C. Taveau, W. Liu, J. Lamy, J. Frank, J.N. Lamy, Three-Dimensional Immunoelectron Microscopy of Scorpion Hemocyanin Labeled with Monoclonal Fab Fragment. J.Structural Biol. 111, (1993), 234-244

M. Radermacher, Three-dimensional reconstruction from random projections: orientational alignment via Radon transforms. Ultramicroscopy 53, 1994, 121-136.

M. Radermacher, V. Rao, R. Grassucci, J. Frank, A.P. Timerman, S. Fleischer, T. Wagenknecht, Cryo-Electron Microscopy and Three-dimensional Reconstruction of the Calcium Release Channel/Ryanodine Receptor from Skeletal Muscle. J. Cell Biol. 127,1994,411-423

S. Srivastava, A. Verschoor, M. Radermacher, R. Grassucci, J. Frank, Three-dimensional reconstruction of mammalian 40S ribosomal subunit embedded in ice. J.Mol.Biol., 245, 1995, 461-466.

J. Frank, J. Zhu, P. Penczek, Y. Li, S. Srivastava, A. Verschoor, M. Radermacher, R. Grassucci, R.K. Lata, R.K. Agrawal, A Model of Protein Synthesis Based on Cryo-Electron Microscopy of the E.coli Ribosome. Nature 376,1995, 441-444

T. Wagenknecht, M. Radermacher , Three-dimensional architecture of the skeletal muscle ryanodine receptor. FEBS Letters 369, 1995. 43-46.

J. Frank, A. Verschoor, Y. Li, J. Zhu, R.K. Lata, M. Radermacher, P. Penczek, R. Grassucci, R.K. Agrawal, S. Srivastava A model of the translational apparatus based on a three-dimensional reconstruction of the Escherichia coli ribosome. Biochemistry & Cell Biology 73, 1995, 757-765.

J. Frank, M. Radermacher, P. Penzcek, J. Zhu, Y. Li, M. Ladjadj, A .Leith, SPIDER and WEB: Processing and visualization of images in 3D electron microscopy and related fields. Journal of Structural Biology 116, 1996. 190-199.

T. Wagenknecht, M. Radermacher, R. Grassucci, J. Berkowitz, H.B. Xin, S. Fleischer Locations of calmodulin and FK506-binding protein on the three-dimensional architecture of the skeletal muscle ryanodine receptor. Journal of Biological Chemistry 272, 1997. 32463-32471.

B.K. Rath, M. Marko, M. Radermacher, J. Frank Low-dose automated electron tomography: A recent implementation. Journal of Structural Biology 120, 1997. 210-218.

M. Radermacher, Radon transform techniques for alignment and three-dimensional reconstruction from random projections. Scanning Microscopy 11, 1997, 171-177; pdf

T. Wagenknecht, M. Radermacher, Ryanodine receptors: structure and macromolecular interactions. Current Opinion in Biology, 7, 1997, 258-265

M. Samso, M. Radermacher, J. Frank, M.P. Koonce, Structural characterization of a dynein motor domain. Journal of Molecular Biology 276, 1998, 927-937.

C.S. Martin, M. Radermacher, B. Wolpensinger, A. Engel, C.S. Miles, N.E. Dixon, J.M. Carazo, Three-dimensional reconstructions from cryoelectron microscopy images reveal an intimate complex between helicase DnaB and its loading partner DnaC. Structure 6, 1998, 501-509.

O. Llorca, M.G. Smyth, J.L. Carrascossa, K.R. Willison, M. Radermacher, J.M. Valpuesta, 3D reconstruction of the ATP-bound form of CCT reveals the asymmetric folding conformation of a type II Chaperonin. Nature Structural Biology, 6, 1999, 639-642

M. Radermacher, T. Ruiz, W.R. Harvey, H. Wieczorek, G. Grüber, Molecular architecture of Manduca sexta midgut V1Atpase visualized by electron microscopy. Febs Letters 453, 1999, 383-386

S. Lanzavecchia, P.L. Bellon, M. Radermacher, Fast and accurate three dimensional reconstruction from projections with random orientations via Radon transforms. J. Structural Biol. J.Struct. Biol. 128, 1999, 152-164

G. Grüber, M. Radermacher, T. Ruiz, J. Godovac-Zimmermann, B. Canas., D. Kleine-Kohlbrecher, M. Huss, W. R. Harvey, H. Wieczorek, Three-dimensional structure and subunit topology of the V1 ATPase from Manduca sexta midgut, Biochemistry 39, 2000, 8609-8616

R. Djafarzadeh, S. Kerscher, K. Zwicker, M. Radermacher, M. Lindahl, H. Schägger, U. Brandt, Biophysical and structural characterization of proton-translocating NADH-Dehydrogenase (complex I) from the strictly aerobic yeast Yarrowia lipolytica. Biochimica et Biophysica Acta 1459, 2000, 230-238

D.G. Morgan, J-F. Ménétret, M. Radermacher, A. Neuhof, I.V. Akey, T.A. Rapoport, C.W. Akey, A comparison of the yeast and rabbit 80S ribosome reveals the topology of the nascent chain exit tunnel, inter-subunit bridges and mammalian rRNA expansion segments. J. Mol. Biol. 301, 2000, 301-321

J.F. Menetret, A. Neuhof, D.G. Morgan, K. Plath, M. Radermacher, T.A. Rapoport,  C.W. Akey. The structure of ribosome-channel complexes engaged in protein translocation. Molecular Cell. 6(5). 2000. 1219-1232.

M. Radermacher, Three-dimensional Reconstruction of Single Particles. in “Image Analysis in Biology, second edition”, (ed. D.P. Häder) CRC Press inc., Bocca Raton 2000

M. Barcena, T. Ruiz. L.E. Donate. S.E. Brown. N.E. Dixon. M. Radermacher, JM. Carazo,  The DnaB  DnaC complex: a structure based on dimers assembled around an occluded channel.  EMBO Journal. 20 (2001), 1462-1468

M. Radermacher, T. Ruiz, H. Wieczorek, G. Grüber The Structure of the V1-ATPase determined by Three-Dimensional Electron Microscopy of Single Particles. Journal of Structural Biology, 135 (2001), 26-37

T. Ruiz, G. Kopperschläger, M. Radermacher. The frirst three-dimensional structure of phosphofructokinase from Saccharomyces cervisiae determined by electron microscopy of single particles. Journal of Structural Biology. 136, (2001), 167-180

K. Model, T. Prinz, T. Ruiz, M. Radermacher, T. Krimmer, W. Kühlbrandt, N. Pfanner, C. Meisinger, Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex.  Journal of Molecular Biology. (2002) 316, (3), 657-666.

M. Samso, M.J. Palumbo, M. Radermacher, J.S .Liu, C.E. Lawrence. A bayesian Method for classification of images from electron micrographs. Journal of Structural Biology 138, (2002) 157-170

S. Lanzavecchia, F. Cantele, M. Radermacher, L.P. Bellon, Symmetry embedding in the reconstruction of macromolecular assemblies via the discrete Radon transform. Journal of Structural Biology. 137, (2002), 259-72

V.F. Rizzo, U. Coskun, M. Radermacher, T. Ruiz, A. Armbruester, G. Grueber, Resolution of the V1 ATPase from Manduca sexta into subcomplexes and visualization of an ATPase-active A3B3EG complex by electron microscopy. Journal of Biological Chemistry.  2003, 270-275.

V.  Zickermann, M. Bostina,  C. Hunte, T. Ruiz, M. Radermacher, U. Brandt, Functional implications from an unexpected position of the 49-kDa subunit of NADH:ubiquinone oxidoreductase. Journal of Biological Chemistry. 2003, 29072-29078.

G. Peng, G. Fritzsch, V. Zickermann, H. Schaegger, R. Mentele, F. Lottspeich, M. Bostina, M. Radermacher, R. Huber;  K.O. Stetter, H. Michel, Isolation, characterization and electron microscopic single particle analysis of the NADH:ubiquinone oxidoreductase (complex I) from the hyperthermophilic eubacterium Aquifex aeolicus. Biochemistry.  42(10). 2003. 3032-3039.

T. Ruiz, I. Mechin, J. Bär, W. Rypniewski, G. Kopperschläger and M. Radermacher. The 10.8 Å Structure of S. cerevisiae Phosphofructokinase determined by Cryo-Electron Microscopy: Localization of the putative Fructose-6-phosphate binding sites. Journal of Structural Biology. 143, (2003) 124-134.

U. Coskun, M. Radermacher, V. Müller, T. Ruiz, Gerhard GrüberThree-dimensional Organization of the Archaeal A1-ATPase from Methanosarcina mazei Gö1. Journal of Biological Chemistry, (2004) 279(21):22759-64

A. Abdrakhmanova, V. Zickermann, M. Bostina, M. Radermacher, H. Schägger, S. Kerscher, U. Brandt Subunit composition of mitochondrial complex I from the yeast Yarrowia lipolytica, Biochimica et Biophysica Acta (BBA) – Bioenergetics, 1658 (1-2) 148-156, 2004

M. Radermacher, T Ruiz. Three-dimensional reconstruction of single particles in electron microscopy: image processing. Methods Mol Biol. 2006;319:427-61.

T Ruiz, M. Radermacher.Three-dimensional analysis of single particles by electron microscopy: sample preparation and data acquisition. Methods Mol Biol. 2006;319:403-25.

M. Radermacher, T. Ruiz, T. Clason, S. Benjamin, U. Brandt, V. Zickermann.The three-dimensional structure of complex I from Yarrowia lipolytica: a highly dynamic enzyme. J Struct Biol. 2006 154(3):269-79.

G. Peng, M. Bostina, M. Radermacher, I. Rais, M. Karas, H. Michel. Biochemical and electron microscopic characterization of the F1F0 ATP synthase from the hyperthermophilic eubacterium Aquifex aeolicus. FEBS Lett. 2006 Oct 30;580(25):5934-40.

T. Ruiz, C. Lenox, M. Radermacher, KP Mintz. Novel surface structures are associated with the adhesion of Actinobacillus actinomycetemcomitans to collagen. Infect Immun.2006 Nov;74(11):6163-70.

F. Cantele, L. Zampighi, M. Radermacher, G. Zampighi, S. Lanzavecchia. Local refinement: An attempt to correct for shrinkage and distortion in electron tomography. J Struct Biol., (2007) 158, 59-70

M. Radermacher, Weighted Back-Projection Methods.  In: Electron Tomography, 2nd edition, (Ed. J. Frank) Springer Verlag, 2007

M. Bárcena, M. Radermacher, J. Bär, G. Kopperschläger; T. Ruiz, The Structure of the ATP-bound State of S. cerevisiae Phosphofructokinase determined by Cryo- Electron Microscopy, Journal of Structural Biology, (2007) 159(1):135-143

T. Clason, V. Zickermann, T. Ruiz, U. Brandt, M. Radermacher, Direct Localization of the 51 kDa and 24 kDa Subunits of Mitochondrial Complex I by Three-dimensional Difference Imaging, Journal of Structural Biology, (2007), 159(3):433-442

S. Benjamin, M. Radermacher, J. Bär, A. Edelmann and T. Ruiz. Structures of S. pombe phosphofructokinase in the F6P-bound and ATP-bound states. Journal of Structural Biology, (2007) 159(3):498-506 .

M. Radermacher, Chapter 1: Visualizing Functional Flexibility by Three-Dimensional Electron Microscopy: Reconstructing Complex I of the Mitochondrial Respiratory Chain. In: Methods in Enzymology, Mitochondrial Function, Part A: Mitochondrial Electron Transport Complexes and Reactive Oxygen Species, Edited by: William S. Allison and Immo E. Scheffler, (2009) Vol. 456, 3-27

V. Zickermann, S. Kerscher, K. Zwicker, M.A. Tocilescu, M. Radermacher, U. Brandt, Architecture of complex I and its implications for electron transfer and proton pumping. Biochim Biophys Acta. (2009) 1787(6): 574-83.

N. R. Voss, C. K. Yoshioka, M. Radermacher, C. S. Potter, B. Carragher, DoG Picker and TiltPicker: software tools to facilitate particle selection in single particle electron microscopy. J Struct Biol, 166(2) (2009):205-213.

S. Benjamin, M. Radermacher, J. Kirchberger, T. Schoneberg, A. Edelmann, T. Ruiz: 3D structure of phosphofructokinase from Pichia pastoris: Localization of the novel gamma-subunits. J Struct Biol, 168(2) (2009):345-351

T. Clason, T. Ruiz, H. Schagger, G. Peng, V. Zickermann, U. Brandt, H. Michel, M. Radermacher: The structure of eukaryotic and prokaryotic complex I. J Struct Biol (2010) 169(1):81-88

L. Yu, R.R. Snapp, T. Ruiz, M. Radermacher, Probabilistic principal component analysis with expectation maximization (PPCA-EM) facilitates volume classification and estimates the missing data. J Struct Biol. 2010, 171(1):18-30

K. Banaszak, I. Mechin, G. Obmolova, M. Oldham, SH. Chang , T. Ruiz, M. Radermacher, G. Kopperschläger, W. Rypniewski. The Crystal Structures of Eukaryotic Phosphofructokinases from Baker’s Yeast and Rabbit Skeletal Muscle. J Mol Biol. 2011, 407(2):284-97

H. Angerer, K. Zwicker, Z. Wumaier, L. Sokolova, H. Heide, M. Steger, S. Kaiser, E. Nübel, B. Brutschy, M. Radermacher, U. Brandt, V. Zickermann, Accessory subunits scaffold functional modules in mitochondrial complex I, Biochem J. 2011, 437(2):279-88

S. Dröse, S. Krack, L. Sokolova, K. Zwicker, H.D. Barth, N. Morgner, H. Heide, M. Steger, E. Nübel, V. Zickermann, S. Kerscher, B. Brutschy, M. Radermacher, U. Brandt. Functional dissection of the proton pumping modules of mitochondrial complex I. PLoS Biol. 2011, 9(8):e1001128.

F. Azari, M. Radermacher, K.P. Mintz, T. Ruiz Correlation of the amino-acid sequence and the 3D structure of the functional domain of EmaA from Aggregatibacter actinomycetemcomitans. J Struct Biol. 2012,177(2):439-46

F. Azari, L. Nyland, C. Yu, M. Radermacher, K.P. Mintz, T.Ruiz. Ultrastructural analysis of the rugose cell envelope of a member of the Pasteurellaceae family. J Bacteriol. 2013195(8):1680-1688

L. Yu, R. R. Snapp, T. Ruiz, M. Radermacher, Projection-based volume alignment, J. Struct. Biol. 2013, J Struct Biol. 2013,182(2):93-105

K. Hatle, P. Gummadidala, E. Bernardo, N. Navasa, J. Dodge, B. Silverstrim, K. Fortner, J. Hammer, M. Radermacher, D. J. Taatjes, J. Anguita, M. Rincon, MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. . Mol Cell Biol. 2013,33(11):2302-14

Angerer H, Radermacher M, Małkowska M, Steger M, Zwicker K, Heide H, Wittig I, BrandtU, Zickermann V. The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5207-12.



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