A member of the David Warshaw Laboratory
My goal is to design, develop, fabricate and support world class microscopy systems for research in molecular physiology. Our research demands high sensitivity with fast temporal and precise spatial resolution. These systems include integrated Laser Optical Tweezers with dual color Total Internal Reflection Microscopy (TIRFM) along with single molecule detection, manipulation and tracking capabilities. Mechanical measurements of pico-newton force, nanometer displacement, and pico-newtons/ nanometer stiffness are used to address questions in single molecules. These techniques are applied to protein ensembles, intercellular dynamics, and molecular protein- protein interactions. High speed fluorescent imaging of single molecule dynamics are possible using state of the art ICCD cameras with TIR and far field illumination. Recent initiatives include high speed 3D tracking, STORM, and PALM Super Resolution microscopy. Myosin, Kinesin, C-Protein, Actin, Microtubules and other Cytoskeletal proteins are studied with our techniques.
Predina JD, Newton A, Kennedy G, Lee MK, Singhal S (2017) Near-Infrared Intraoperative Imaging Can Successfully Identify Malignant Pleural Mesothelioma After Neoadjuvant Chemotherapy. Mol Imaging 16: 1536012117723785.
Akhter A, Walker A, Heise CP, Kennedy GD, Benson ME, Pfau PR, Johnson EA, Frick TJ, Gopal DV (2017) A tertiary care hospital’s 10 years’ experience with rectal ultrasound in early rectal cancer. Endosc Ultrasound : .
Kennedy GT, McMillan MT, Maggino L, Sprys MH, Vollmer CM Jr (2017) Surgical experience and the practice of pancreatoduodenectomy. Surgery 162(4): 812-822.
Gunnells DJ Jr, Wood LN, Goss L, Morris MS, Kennedy GD, Cannon JA, Chu DI (2017) Racial Disparities After Stoma Construction Exist in Time to Closure After 1 Year but Not in Overall Stoma Reversal Rates. J Gastrointest Surg : .
Kennedy GT, Lentsch GR, Trieu B, Ponticorvo A, Saager RB, Durkin AJ (2017) Solid tissue simulating phantoms having absorption at 970 nm for diffuse optics. J Biomed Opt 22(7): 76013.
Kennedy GT, Newton A, Predina J, Singhal S (2017) Intraoperative near-infrared imaging of mesothelioma. Transl Lung Cancer Res 6(3): 279-284.
Pankratz DG, Choi Y, Imtiaz U, Fedorowicz GM, Anderson JD, Colby TV, Myers JL, Lynch DA, Brown KK, Flaherty KR, Steele MP, Groshong SD, Raghu G, Barth NM, Walsh PS, Huang J, Kennedy GC, Martinez FJ (2017) Usual Interstitial Pneumonia Can Be Detected in Transbronchial Biopsies Using Machine Learning. Ann Am Thorac Soc : .