Gregory Hoeprich


Gregory  Hoeprich,

Graduate Student

Background

I received my B.A. in Chemistry and Zoology from Miami University in 2006 and my M.A. in Medical Sciences from Boston University in 2008. While a student at Boston University, I worked in Jeffrey Moore’s Lab on reconstituted myosin filaments.

Contact

Office:
Given E217
802-656-5707

Lab:
Given E215


Lab Group

A member of the Christopher Berger Laboratory

Research Description

Axonal transport is a complex and highly regulated process that traffics cargo to specific locations within the axon. Molecular motors actively transport this cargo through a complex microtubule landscape, which is decorated with microtubule associated proteins (MAPs). I am investigating two kinesin motor proteins, kinesin-1 and kinesin-2, as they are both known to traffic cargo along the microtubule. The focus of my research surrounds the structural and functional roles of the kinesin neck-linker, which affects the motor’s gating mechanism, and how these differences translate to their ability to navigate the complicated microtubule environment within the axon.

 

Highlighted Publications

Weith AE, Previs MJ, Hoeprich GJ, Previs SB, Gulick J, Robbins J, Warshaw DM. The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded manner. J. Muscle Res. Cell Motil. 2012. 33(6):449-59.

All Hoeprich publications