{"id":17,"date":"2013-02-04T02:46:54","date_gmt":"2013-02-04T02:46:54","guid":{"rendered":"http:\/\/physioweb.physiol.w3.uvm.edu\/stumpff-lab\/?page_id=13"},"modified":"2022-08-27T12:13:50","modified_gmt":"2022-08-27T16:13:50","slug":"publications","status":"publish","type":"page","link":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
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PREPRINTS<\/span><\/strong><\/h2>Thompson AF, Blackburn PR, Babovic-Vuksanovic D, Lian JB, Klee EW, and Stumpff J. (2021<\/span>) Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation. bioRxiv doi: https:\/\/www.biorxiv.org\/content\/10.1101\/2021.09.29.462402v2.<\/span>https:\/\/www.biorxiv.org\/content\/10.1101\/2021.09.29.462402v2<\/a><\/span> (final version published in eLife<\/a> June 22, 2022)\n\n\n
Solon AL*, Tan Z*, Schutt KL, Jepsen L, Haynes SE, Nesivizhskii AI, Sept D, Stumpff J, Ohi R, and Cianfrocco MA  (2021<\/span><\/span>) Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding. bioRxiv doi: https:\/\/doi.org\/10.1101\/2021.06.02.446814<\/a> (*equal contribution) (Final version published in Sci Adv<\/a> Nov 19, 2021)<\/p>\n
Sepaniac LA, Martin W, Dionne LA, Stearns TM, *Reinholdt LG, and *Stumpff J (2020<\/span><\/span>) Micronuclei arising due to loss of KIF18A form stable micronuclear envelopes and do not promote tumorigenesis. bioRxiv doi: https:\/\/doi.org\/10.1101\/2020.11.23.394924<\/a> (*co-corresponding authors) (final version published in JCB <\/a> Sept 13th, 2021)<\/p>\n
Marquis C, Fonseca CL, Wood L, Malaby HLH, Clayton JE, and Stumpff J. (2020<\/span><\/span>). Chromosomally unstable tumor cells specifically require KIF18A for proliferation. bioRxiv doi: https:\/\/doi.org\/10.1101\/2020.06.18.159327<\/a><\/p>\n
Cohen-Sharir Y, McFarland JM, Abdusamad M, Marquis C, Tang H, Ippolito MR, Bernhard SV, Laue K, Malaby HLH, Jones A, Kazachkova M, Lyons N, Nagaraja A, Bass AJ, Beroukhim R, Santaguida S, Stumpff J, Golub TR, Storchova Z, and Ben-David U. (202<\/span>0<\/span>). Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint. bioRxiv doi: https:\/\/doi.org\/10.1101\/2020.06.18.159038 <\/a>(Final version published in Nature<\/a> Jan 27, 2021)<\/p>\n
Malaby HLH, Lessard DV, Berger CL, and Stumpff J. (2018<\/span><\/span>). Human kinesin Kif18A\u2019s neck linker permits navigation of microtubule bound obstacles within the mitotic spindle. bioRxiv doi: https:\/\/doi.org\/10.1101\/364380<\/a> (final version published in Life Science Alliance <\/a>Jan 17th, 2019)<\/p>\n
Fonseca CL, Malaby HLH, Sepaniac LA, Martin W, Byers C, Czechanski A, Messinger D, Tang ME, Ohi R, Reinholdt LG, and Stumpff J. (2018<\/span><\/span>). Mitotic chromosome alignment is required for proper nuclear envelope reassembly. bioRxiv doi: https:\/\/doi.org\/10.1101\/343475<\/a>, highlighted by preLights<\/a> (final version published in JCB<\/a> Feb 7th, 2019)<\/p>\n
Malaby H, Dumas M, Ohi R, and Stumpff J. (201<\/span>8<\/span>). Kinesin binding protein (KBP) buffers the activity of Kif18A and Kif15 in mitosis to ensure accurate chromosome segregation. bioRxiv doi: https:\/\/doi.org\/10.1101\/343046<\/a>. (final version published in JCB<\/a> Feb 1st, 2019)<\/p>\n
Kim H and Stumpff J. (2018<\/span><\/span>). Kif18A promotes Hec1 dephosphorylation to coordinate chromosome alignment with kinetochore microtubule attachment. bioRxiv doi: https:\/\/doi.org\/10.1101\/304147<\/a>.<\/p>\n
SELECTED PUBLICATIONS<\/span><\/strong><\/h2>Thompson AF, Blackburn PR, Babovic-Vuksanovic D, Lian JB, Klee EW, and Stumpff J. Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation<\/a><\/span><\/span>.  <\/span>eLife. 2022<\/span> 11:e78653 PMID: 35730929\n\nThompson AF, Vandal S, Stumpff J. Quantifying changes in chromosome position to access chromokinesin activity. In Hinchcliffe EH (Ed.), Mitosis: Methods and Protocols. 2022<\/span> New York, NY: Springer Science & Business Media, LLC. <\/span>PMID: 34972951\n\n\nSolon AL*, Tan Z*, Schutt KL, Jepsen L, Haynes SE, Nesivizhskii AI, Sept D, Stumpff J, Ohi R, and Cianfrocco MA. Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding<\/a>. Science Advances. 2021<\/span> 7(47). PMID: 34797717 (*equal contribution).<\/span>\n\n\n
Sepaniac LA, Martin W, Dionne LA, Stearns TM, *Reinholdt LG, and *Stumpff J. <\/span>  Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis. <\/a>, JCB<\/strong><\/em>. 2021<\/span><\/span> 220 (11). PMID:34515734 (*co-corresponding authors) <\/span><\/p>\n
Marquis C, Fonseca CL, Queen KA, Wood L, Vandal SE, Malaby HLH, Clayton JE, and Stumpff J. Chromosomally unstable tumor cells specifically require KIF18A for proliferation<\/a>. Nat Comm<\/strong><\/em>. 2021<\/span><\/span> 12: 1213. PMID: 33619254.<\/p>\n
Cohen-Sharir Y, McFarland JM, Abdusamad M, Marquis C, Tang H, Ippolito MR, Bernhard SV, Laue K, Malaby HLH, Jones A, Kazachkova M, Lyons N, Nagaraja A, Bass AJ, Beroukhim R, Santaguida S, Stumpff J, Golub TR, Storchova Z, and Ben-David U. Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint<\/a>. Nature<\/strong><\/em> 2021<\/span><\/span>, 590: 486-491. PMID: 33505028<\/p>\n
Bodrug T, Wilson-Kubalek EM, Nithianantham S, Thompson AF, Alfieri A, Gaska I, Major J, Debs G, Inagaki S, Gutierrez P, Gheber L, McKenney RJ, Sindelar CV, Milligan R, Stumpff J, Rosenfeld SS, Forth ST, and Al-Bassam J. The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding<\/a>. eLife<\/strong><\/em>. 2020<\/span><\/span> PMID: 31958056.<\/p>\n
Fonseca CL, Malaby HLH, Sepaniac LA, Martin W, Byers C, Czechanski A, Messinger D, Tang ME, Ohi R, Reinholdt LG, and Stumpff J. Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase<\/a>.\u00a0JCB<\/strong><\/em>.\u00a0<\/strong><\/em>2019<\/span><\/span>, 218:1148-1163. PMID: 30733233<\/p>\n
Malaby H, Dumas M, Ohi R, and Stumpff J. Kinesin binding protein ensures accurate chromosome segregation by buffering Kif18A and Kif15.<\/a> JCB<\/strong><\/em>.\u00a0<\/strong><\/em>2019<\/span><\/span>, 218:1218-1234. PMID: 30709852<\/p>\n
Malaby HLH, Lessard DV, Berger CL, and Stumpff J.\u00a0 KIF18A\u2019s neck linker permits navigation of microtubule-bound obstacles within the mitotic spindle<\/a>.\u00a0 LSA<\/strong><\/em>. 2019<\/span><\/span>, 2:e201800169. PMID: 30655363<\/p>\n
Muretta JM, Reddy BJN, Scarabelli G, Thompson AF, Jariwala S, Major J, Venere M, Rich JN, Willard B, Thomas DD, Stumpff J, Grant BJ, Gross SP, Rosenfeld SS. A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function<\/a>. PNAS<\/strong><\/em>. 2018<\/span><\/span>, 115: E1779-E1788. PMID: 29432173.<\/p>\n
Tracy KM, Tye CE, Ghule PN, Malaby HLH, Stumpff J, Stein LJ, Stein GS, Lian JB. Mitotically-associated lncRNA (MANCR) affects genomic stability and cell division in aggressive breast cancer<\/a>. Mol Cancer Res<\/strong><\/em>. 2018<\/span><\/span>. PMID: 29378907.<\/p>\n
Zhou J, Chan J, Lambel\u00e9 M, Yusufzai T, Stumpff J<\/b>, Opresko PL, Thali M, Wallace SS. NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis<\/a>. Cell Reports<\/strong><\/em>. 2017<\/span>, 20: 2044-2056. PMID: 28854357.<\/p>\n
Fonseca C and Stumpff J. Quantification of mitotic chromosome alignment<\/a>. Methods Mol Biol<\/strong><\/em>. 2016<\/span>, 1413: 253-62. PMID: 27193854. PDF_Fonseca_2016<\/a><\/span><\/p>\n
Czechanski A, Kim H, Byers C, Greenstein I, Stumpff J<\/b>*, Reinholdt LG*. Kif18a Is specifically required for mitotic progression during germ line development<\/a>. Dev Biol<\/em><\/strong>. 2015<\/span> June 15,\u00a0402(2):253-62 .PMID:25824710. (*corresponding authors) PDF_Czechanski_2015<\/span><\/a><\/p>\n
Malaby, HLH and Stumpff, J. Microtubule recognition: A curvy attraction<\/a>. Curr Biol<\/strong><\/em>. 2014<\/span> Oct 24 (20): R998-R1000. PDF_Malaby_2014<\/span><\/a><\/span><\/p>\n
Kim H, Fonseca C and Stumpff J. A unique kinesin-8 surface loop provides specificity for chromosome alignment<\/a>.\u00a0 Mol Biol Cell<\/em><\/strong>. 2014<\/span> Nov 25 (21): 3319-3329.\u00a0 PMID: 25208566. PDF_Kim_2014<\/span><\/a><\/span><\/p>\n
Stumpff J, Ghule PN, Shimamura A, Stein JL, Greenblatt M. Spindle microtubule dysfunction and cancer predisposition<\/a>.\u00a0 J Cell Physiol<\/em><\/strong>. 2014<\/span> Dec, 229 (12): 1881-3. doi: 10.1002\/jcp.24691. PMID: 24905602 PDF_Stumpff_2014_JCP<\/span><\/a><\/span><\/p>\n
Bissonette S, Stumpff J.\u00a0Quantifying Mitotic Chromosome Dynamics and Positioning<\/a>.\"Journal\u00a0 J Cell Physiol<\/em><\/strong>. 2014<\/span> Oct 229(10):1301-05. doi: 10.1002\/jcp.24634. PMID: 24683081 PDF_Bissonette_2014<\/span><\/a><\/span>\n\n(Featured on journal Cover<\/a>)<\/p>\n
Cunniff B, Snider GW, Fredette N, Stumpff J, Hondal RJ, Heintz NH. Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine.<\/a> Redox Biol<\/em><\/strong>. 2014<\/span> Feb 19;2:475-84. doi: 10.1016\/j.redox.2014.01.021. PMID: 24624337 PDF_Cunniff_2014<\/span><\/a><\/span><\/p>\n
Cunniff B, Benson K, Stumpff J, Newick K, Held P, Taatjes D, Joseph J, Kalyanaraman B, Heintz NH. Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells.<\/a>\u00a0 J Cell Physiol.<\/strong><\/em> 2013<\/span> Apr;228(4):835-45. doi: 10.1002\/jcp.24232. PMID: 23018647 PDF_Cunniff_2013<\/span><\/a><\/span>\n\n(Featured on journal Cover<\/a>)<\/p>\n
Stumpff J. Measuring microtubule thickness: an exercise in cooperativity.<\/a>\u00a0 Dev Cell<\/em><\/strong>. 2012<\/span> Jul 17;23(1):1-2. doi: 10.1016\/j.devcel.2012.06.010. PMID: 22814594 PDF_Stumpff_2012_DC2<\/span><\/a><\/span><\/p>\n
Stumpff J**, Wagenbach M, Franck A, Asbury CL, Wordeman L** Kif18A and chromokinesins confine centromere movements via microtubule growth suppression and spatial control of kinetochore tension. <\/a>Dev Cell<\/em><\/strong>. 2012<\/span> May 15;22(5):1017-29. doi: 10.1016\/j.devcel.2012.02.013. PMID: 22595673 PDF_Stumpff_2012_DC1<\/span><\/a><\/span>\n\n(** co-corresponding authors) (Featured on journal Cover<\/strong><\/a>) (Cited on F1000 Prime<\/strong><\/a>)<\/p>\n
Stumpff J**, Du Y**, English CA, Maliga Z, Wagenbach M, Asbury CL, Wordeman L, Ohi R. A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.<\/a>\u00a0 Mol Cell<\/strong><\/em>. 2011<\/span> Sep 2;43(5):764-75. doi: 10.1016\/j.molcel.2011.07.022. PMID: 21884977 PDF_Stumpff_2011<\/span><\/a><\/span>\n\n(** authors contributed equally) (Cited on F1000 Prime<\/strong><\/a>)<\/p>\n
Mattison CP, Stumpff J, Wordeman L, Winey M. Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning.<\/a>\u00a0 Cell Cycle<\/strong><\/em>. 2011<\/span> Mar 1;10(5):783-93. Epub 2011 Mar 1. PMID: 21325884 PDF_Mattison_2011<\/span><\/a><\/span>\n\n(Featured on journal Cover<\/strong><\/a>)<\/p>\n
Wordeman L, Stumpff J. Microtubule length control, a team sport?<\/a> Dev Cell.<\/strong><\/em> 2009<\/span> Oct;17(4):437-8. doi: 10.1016\/j.devcel.2009.10.002. PMID: 9853556 PDF_Wordeman_2009<\/span><\/a><\/span><\/p>\n
Garcia K, Stumpff J, Duncan T, Su TT. Tyrosines in the kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrity.<\/a>\u00a0 Curr Biol<\/strong><\/em>. 2009<\/span> Oct 13;19(19):1670-6. doi: 10.1016\/j.cub.2009.08.013. Epub 2009 Oct 1. PMID: 19800237 PDF_Garcia_2009<\/span><\/a><\/span><\/p>\n
Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L. The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment.<\/a> Dev Cell<\/strong><\/em>. 2008<\/span> Feb;14(2):252-62. doi: 10.1016\/j.devcel.2007.11.014. PMID: 18267093 PDF_Stumpff_2008_DevCell<\/span><\/a><\/span>\n\n(Cited on F1000 Prime<\/strong><\/a>)<\/p>\n
Stumpff J, Asbury CL. Chromosome bi-orientation: Euclidian euploidy.<\/a>\u00a0 Curr Biol<\/strong><\/em>. 2008<\/span> Jan 22;18(2):R81-3. doi: 10.1016\/j.cub.2007.11.036. PMID: 18211848 PDF_Stumpff_2008_CurrBiol<\/span><\/a><\/span><\/p>\n
Stumpff J, Cooper J, Domnitz S, Moore AT, Rankin KE, Wagenbach M, Wordeman L. In vitro and in vivo analysis of microtubule-destabilizing kinesins.<\/a>\u00a0 Methods Mol Biol. <\/strong><\/em>2007<\/span> ;392:37-49. PMID: 17951709<\/p>\n
Stumpff J, Wordeman L.\u00a0 Chromosome congression: the kinesin-8-step path to alignment.<\/a> Curr Biol.<\/strong><\/em> 2007<\/span> May 1;17(9):R326-8. Review. PMID: 17470346 PDF_Stumpff_2007<\/span><\/a><\/span><\/p>\n
Stumpff J, Kellogg DR, Krohne KA, Su TT.\u00a0 Drosophila Wee1 interacts with members of the gammaTURC and is required for proper mitotic-spindle morphogenesis and positioning.<\/a> Curr Biol.<\/em><\/strong> 2005<\/span> Sep 6;15(17):1525-34. PMID: 16139207 PDF_Stumpff_2005<\/span><\/a><\/span><\/p>\n
Stumpff J, Duncan T, Homola E, Campbell SD, Su TT. Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis.<\/a> Curr Biol.<\/strong><\/em> 2004<\/span> Dec 14;14(23):2143-8. PMID: 15589158 PDF_Stumpff_2004<\/span><\/a><\/span>\n\n(Cited on F1000 Prime<\/strong>)<\/p>\n
Su TT, Walker J, Stumpff J. Activating the DNA damage checkpoint in a developmental context.<\/a>\u00a0 Curr Biol.<\/em><\/strong> 2000<\/span> Feb 10;10(3):119-26. PMID: 10679321 PDF_Su_2000<\/span><\/a><\/span><\/p>\n
Full list of Dr. Stumpff's publications on Pubmed <\/a><\/h3><\/code><\/pre>\n\n\n\n
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