{"id":465,"date":"2015-04-01T12:01:16","date_gmt":"2015-04-01T16:01:16","guid":{"rendered":"http:\/\/physioweb.uvm.edu\/stumpff-lab\/?p=465"},"modified":"2015-04-01T12:04:31","modified_gmt":"2015-04-01T16:04:31","slug":"our-paper-with-laura-reinholdt-describing-germ-cell-defects-in-kif18a-mutant-mice-has-been-published-in-dev-biol","status":"publish","type":"post","link":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/2015\/04\/01\/our-paper-with-laura-reinholdt-describing-germ-cell-defects-in-kif18a-mutant-mice-has-been-published-in-dev-biol\/","title":{"rendered":"The Reinholdt and Stumpff labs have published a new study of Kif18a mutant mice in Developmental Biology"},"content":{"rendered":"<p>Through a great collaboration with <a href=\"http:\/\/research.jax.org\/faculty\/laura-reinholdt.html\" target=\"_blank\">Laura Reinholdt&#8217;s lab<\/a>, we discovered that the mitotic kinesin, Kif18A, is required for cell division in germ cells but not somatic cells. Kif18A plays a central role in aligning chromosomes during metaphase. Interestingly, somatic cells lacking Kif18A divide without aligning their chromosomes. We&#8217;re now trying to understand why Kif18A is specifically required in the germline and how segregating chromosomes in the absence of alignment impacts genomic stability.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Through a great collaboration with Laura Reinholdt&#8217;s lab, we discovered that the mitotic kinesin, Kif18A, is required for cell division in germ cells but not somatic cells. Kif18A plays a central role in aligning chromosomes during metaphase. Interestingly, somatic cells &hellip; <a href=\"https:\/\/physioweb.uvm.edu\/stumpff-lab\/2015\/04\/01\/our-paper-with-laura-reinholdt-describing-germ-cell-defects-in-kif18a-mutant-mice-has-been-published-in-dev-biol\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts\/465"}],"collection":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/comments?post=465"}],"version-history":[{"count":4,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts\/465\/revisions"}],"predecessor-version":[{"id":469,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts\/465\/revisions\/469"}],"wp:attachment":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/media?parent=465"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/categories?post=465"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/tags?post=465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}