{"id":670,"date":"2019-01-18T06:57:04","date_gmt":"2019-01-18T11:57:04","guid":{"rendered":"http:\/\/physioweb.uvm.edu\/stumpff-lab\/?p=670"},"modified":"2019-02-07T07:13:32","modified_gmt":"2019-02-07T12:13:32","slug":"our-study-describing-the-molecular-basis-of-kif18as-accumulation-at-kmt-ends-is-out-in-lsa","status":"publish","type":"post","link":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/2019\/01\/18\/our-study-describing-the-molecular-basis-of-kif18as-accumulation-at-kmt-ends-is-out-in-lsa\/","title":{"rendered":"Our study describing the molecular basis of KIF18A&#8217;s accumulation at kMT ends is out in LSA"},"content":{"rendered":"<p>Heidi Malaby and Dominique Lessard (<a href=\"http:\/\/physioweb.uvm.edu\/faculty-profile\/?user=Christopher_Berger\" target=\"_blank\" rel=\"noopener\">Berger Lab<\/a>) use a combination of quantitative cell imaging and single molecule motility assays to show that KIF18A&#8217;s relatively long neck linker permits navigation of microtubules in the presence of microtubule-associated proteins and concentration of the motor at kinetochore microtubule (kMT) ends.\u00a0 This work suggests that KIF18A&#8217;s ability to move around obstacles on microtubules is required for its chromosome alignment function. You can read the whole paper <a href=\"http:\/\/www.life-science-alliance.org\/content\/2\/1\/e201800169\" target=\"_blank\" rel=\"noopener\">here<\/a> in Life Science Alliance (open access).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Heidi Malaby and Dominique Lessard (Berger Lab) use a combination of quantitative cell imaging and single molecule motility assays to show that KIF18A&#8217;s relatively long neck linker permits navigation of microtubules in the presence of microtubule-associated proteins and concentration of &hellip; <a href=\"https:\/\/physioweb.uvm.edu\/stumpff-lab\/2019\/01\/18\/our-study-describing-the-molecular-basis-of-kif18as-accumulation-at-kmt-ends-is-out-in-lsa\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts\/670"}],"collection":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/comments?post=670"}],"version-history":[{"count":2,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts\/670\/revisions"}],"predecessor-version":[{"id":672,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts\/670\/revisions\/672"}],"wp:attachment":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/media?parent=670"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/categories?post=670"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/tags?post=670"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}