{"id":680,"date":"2019-02-10T11:23:19","date_gmt":"2019-02-10T16:23:19","guid":{"rendered":"http:\/\/physioweb.uvm.edu\/stumpff-lab\/?p=680"},"modified":"2019-02-10T11:23:44","modified_gmt":"2019-02-10T16:23:44","slug":"our-collaborative-study-of-why-chromosomes-align-during-mitosis-is-out-in-jcb","status":"publish","type":"post","link":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/2019\/02\/10\/our-collaborative-study-of-why-chromosomes-align-during-mitosis-is-out-in-jcb\/","title":{"rendered":"Our study of why chromosomes align during mitosis is out in JCB"},"content":{"rendered":"<p>In collaboration with <a href=\"https:\/\/www.jax.org\/research-and-faculty\/research-labs\/the-reinholdt-lab\" target=\"_blank\" rel=\"noopener\">Laura Reinholdt<\/a> at the Jackson Laboratory, we used cell culture and mouse models lacking <em>Kif18a<\/em> function to investigate the consequences of cell division in the absence of chromosome alignment. These studies suggest that a major function of chromosome alignment is to promote interchromosomal compaction during anaphase and organization of all chromosomes into a single, ovoid nucleus at the completions of cell division. You can find the manuscript in <a href=\"http:\/\/jcb.rupress.org\/content\/early\/2019\/02\/06\/jcb.201807228\" target=\"_blank\" rel=\"noopener\">JCB here<\/a>. Congratulations to Stumpff lab members Cindy Fonseca, Heidi Malaby, Leslie Sepaniac, and Dana Messinger and Reinholdt lab members <span class=\"highwire-citation-authors\"><span class=\"highwire-citation-author has-tooltip hasTooltip\">Whitney Martin<\/span>, <span class=\"highwire-citation-author\">Candice Byers<\/span>, and <span class=\"highwire-citation-author has-tooltip hasTooltip author-popup-hover\">Anne Czechanski <\/span><\/span>on a very story!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In collaboration with Laura Reinholdt at the Jackson Laboratory, we used cell culture and mouse models lacking Kif18a function to investigate the consequences of cell division in the absence of chromosome alignment. These studies suggest that a major function of &hellip; <a href=\"https:\/\/physioweb.uvm.edu\/stumpff-lab\/2019\/02\/10\/our-collaborative-study-of-why-chromosomes-align-during-mitosis-is-out-in-jcb\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts\/680"}],"collection":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/comments?post=680"}],"version-history":[{"count":2,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts\/680\/revisions"}],"predecessor-version":[{"id":682,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/posts\/680\/revisions\/682"}],"wp:attachment":[{"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/media?parent=680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/categories?post=680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/physioweb.uvm.edu\/stumpff-lab\/wp-json\/wp\/v2\/tags?post=680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}