Brandon Matthew Bensel, Ph.D.
I received my Bachelor of Science in Molecular Biology from Lehigh University in Bethlehem, PA in May 2013, and then transitioned to Rensselaer Polytechnic Institute in Troy, NY for my graduate studies. My PhD work was completed in the lab of Dr. Susan P. Gilbert, and I received my PhD in Biology in May 2019.
A member of the David Warshaw Laboratory
The proper delivery of cellular cargoes via intracellular transport is necessary to ensure healthy cellular function. To date, much work has been done to understand the mechanisms which regulate cargo transport in vitro, yet much of this work is done in 2 dimensions with a single type of motor on a rigid cargo, which may not recapitulate the physiological system. My work aims to understand how teams of multiple kinesin and myosin molecular motors navigate complex 3-dimensional networks of microtubules and actin filaments while bound to artificial liposome cargoes.
Bensel BM, Guzik-Lendrum S, Masucci EM, Woll KA, Eckenhoff RG, Gilbert SP. Common general anesthetic propofol impairs kinesin processivity. Proc Natl Acad Sci U S A. 2017; 114(21):E4281-E4287.
Woll, KA, Guzik-Lendrum, S, Bensel, BM, Bhanu, NV, Dailey, WP, Garcia, BA, Gilbert, SP, Eckenhoff, RG. An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules. J Biol Chem. 2018 July 20; 293(20):11283-11295.
Guzik-Lendrum S, Rank KC, Bensel BM, Taylor KC, Rayment I, Gilbert SP. Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules. Biophys J. 2015; 109(7):1472-82.
Rensselaer Founders Award of Excellence 2018
CBIS GSA Vice President 2014-2015