Recent Publications

Current Publications:

Lombardo AT, Nelson SR, Kennedy GG, Trybus KM, Walcott S, Warshaw DM (2019) Myosin Va transport of liposomes in three-dimensional actin networks is modulated by actin filament density, position, and polarity. Proc Natl Acad Sci U S A 116(17): 8326-8335.

Inchingolo AV, Previs SB, Previs MJ, Warshaw DM, Kad NM (2019) Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding. Proc Natl Acad Sci U S A 116(14): 6828-6835.

Nelson SR, Kathe SD, Hilzinger TS, Averill AM, Warshaw DM, Wallace SS, Lee AJ (2019) Single molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant. Nucleic Acids Res 47(6): 3058-3071.

Powell CJ, Ramaswamy R, Kelsen A, Hamelin DJ, Warshaw DM, Bosch J, Burke JE, Ward GE, Boulanger MJ (2018) Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii. Proc Natl Acad Sci U S A 115(45): E10548-E10555.

Papadaki M, Holewinski RJ, Previs SB, Martin TG, Stachowski MJ, Li A, Blair CA, Moravec CS, Van Eyk JE, Campbell KS, Warshaw DM, Kirk JA (2018) Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function. JCI Insight 3(20): .

Lin BL, Li A, Mun JY, Previs MJ, Previs SB, Campbell SG, Dos Remedios CG, Tombe PP, Craig R, Warshaw DM, Sadayappan S (2018) Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner. Sci Rep 8(1): 2604.

Powell CJ, Jenkins ML, Parker ML, Ramaswamy R, Kelsen A, Warshaw DM, Ward GE, Burke JE, Boulanger MJ (2017) Dissecting the molecular assembly of the Toxoplasma gondii MyoA motility complex. J Biol Chem 292(47): 19469-19477.

Lombardo AT, Nelson SR, Ali MY, Kennedy GG, Trybus KM, Walcott S, Warshaw DM (2017) Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro. Nat Commun 8: 15692.

Whitelaw JA, Latorre-Barragan F, Gras S, Pall GS, Leung JM, Heaslip A, Egarter S, Andenmatten N, Nelson SR, Warshaw DM, Ward GE, Meissner M (2017) Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion. BMC Biol 15(1): 1.

Ali MY, Vilfan A, Trybus KM, Warshaw DM (2016) Cargo Transport by Two Coupled Myosin Va Motors on Actin Filaments and Bundles. Biophys J 111(10): 2228-2240.

Sckolnick M, Krementsova EB, Warshaw DM, Trybus KM (2016) Tropomyosin isoforms bias actin track selection by vertebrate myosin Va. Mol Biol Cell 27(19): 2889-97.

Heaslip AT, Nelson SR, Warshaw DM (2016) Dense granule trafficking in Toxoplasma gondii requires a unique class 27 myosin and actin filaments. Mol Biol Cell 27(13): 2080-9.

Warshaw DM (2016) HEART DISEASE. Throttling back the heart’s molecular motor. Science 351(6273): 556-7.

Previs MJ, Mun JY, Michalek AJ, Previs SB, Gulick J, Robbins J, Warshaw DM, Craig R (2016) Phosphorylation and calcium antagonistically tune myosin-binding protein C’s structure and function. Proc Natl Acad Sci U S A 113(12): 3239-44.

Michalek AJ, Kennedy GG, Warshaw DM, Ali MY (2015) Flexural Stiffness of Myosin Va Subdomains as Measured from Tethered Particle Motion. J Biophys 2015: 465693.

Previs MJ, Prosser BL, Mun JY, Previs SB, Gulick J, Lee K, Robbins J, Craig R, Lederer WJ, Warshaw DM (2015) Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling. Sci Adv 1(1): .

Heaslip AT, Nelson SR, Lombardo AT, Beck Previs S, Armstrong J, Warshaw DM (2014) Cytoskeletal dependence of insulin granule movement dynamics in INS-1 beta-cells in response to glucose. PLoS One 9(10): e109082.

Nelson SR, Trybus KM, Warshaw DM (2014) Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va. Proc Natl Acad Sci U S A 111(38): E3986-95.

Mukherjea M, Ali MY, Kikuti C, Safer D, Yang Z, Sirkia H, Ropars V, Houdusse A, Warshaw DM, Sweeney HL (2014) Myosin VI must dimerize and deploy its unusual lever arm in order to perform its cellular roles. Cell Rep 8(5): 1522-32.

Nelson SR, Dunn AR, Kathe SD, Warshaw DM, Wallace SS (2014) Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases. Proc Natl Acad Sci U S A 111(20): E2091-9.

Lee AJ, Warshaw DM, Wallace SS (2014) Insights into the glycosylase search for damage from single-molecule fluorescence microscopy. DNA Repair (Amst) 20: 23-31.

Mun JY, Previs MJ, Yu HY, Gulick J, Tobacman LS, Beck Previs S, Robbins J, Warshaw DM, Craig R (2014) Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism. Proc Natl Acad Sci U S A 111(6): 2170-5.

Previs MJ, Michalek AJ, Warshaw DM (2014) Molecular modulation of actomyosin function by cardiac myosin-binding protein C. Pflugers Arch 466(3): 439-44.

Sckolnick M, Krementsova EB, Warshaw DM, Trybus KM (2013) More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va. J Biol Chem 288(41): 29313-22.

Michalek AJ, Howarth JW, Gulick J, Previs MJ, Robbins J, Rosevear PR, Warshaw DM (2013) Phosphorylation modulates the mechanical stability of the cardiac myosin-binding protein C motif. Biophys J 104(2): 442-52.

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