Heidi Malaby and Meghan Dumas (Ohi Lab) use quantitative cell imaging and protein biochemistry to show that KBP functions to buffer the activities of KIF18A and KIF15 during mitosis. You can find the Journal of Cell Biology article describing this work here.
Heidi Malaby and Dominique Lessard (Berger Lab) use a combination of quantitative cell imaging and single molecule motility assays to show that KIF18A’s relatively long neck linker permits navigation of microtubules in the presence of microtubule-associated proteins and concentration of the motor at kinetochore microtubule (kMT) ends. This work suggests that KIF18A’s ability to move around obstacles on microtubules is required for its chromosome alignment function. You can read the whole paper here in Life Science Alliance (open access).
Our recent Preprint describing the function of chromosome alignment was selected by Maiko Kitaoko for a highlight on preLights.
Through collaborations with the Reinholdt, Tang, and Ohi labs, we show that loss of chromosome alignment leads to defects in nuclear envelope reassembly at the completion of mitosis. You can read the preprint here. Congrats to Stumpff lab members Cindy Fonseca, Heidi Malaby, Leslie Sepaniac, and Dana Messinger!
You can read Haein’s paper here. Congrats Haein!
Alex received this year’s Cathy Bulman Award for Best Poster Presentation for her work on the effects of Eg5 acetylation. Congratulations Alex!
Leslie Sepaniac and Alex Thompson were awarded the 1st and 2nd place prizes, respectively, for their talks at the Graduate Student and Postdoctoral Trainee Research showcase, which was part of the Larner College of Medicine’s Excellence in Research Celebration. Congrats Leslie and Alex!
Heidi organized and chaired the first ever Motile and Contractile Systems Gordon Research Symposium for students and postdocs. The one day symposium took place just before the start of the GRC.