Preprints describing vulnerabilities of aneuploid/ CIN cells have been posted

Three manuscripts describing possible approaches to specifically inhibit the growth of aneuploid and chromosomally unstable cancer cells were recently posted on bioRxiv. Our lab contributed to two of these studies, one in collaboration with Uri Ben-David at Tel Aviv University, and we were happy to coordinate preprint submission with Neil Ganem and his lab’s work on cells that have undergone whole genome duplication.

Please check out all 3 papers if you’re interested:

Alex Thompson awarded F31 NIH fellowship

Alex Thompson was awarded an F31 NRSA fellowship from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) to investigate the “Molecular etiology of Spondyloepimetaphyseal Dysplasia with joint laxity, leptodactylic type.” Congratulations Alex!

Our study of why chromosomes align during mitosis is out in JCB

In collaboration with Laura Reinholdt at the Jackson Laboratory, we used cell culture and mouse models lacking Kif18a function to investigate the consequences of cell division in the absence of chromosome alignment. These studies suggest that a major function of chromosome alignment is to promote interchromosomal compaction during anaphase and organization of all chromosomes into a single, ovoid nucleus at the completions of cell division. You can find the manuscript in JCB here. Congratulations to Stumpff lab members Cindy Fonseca, Heidi Malaby, Leslie Sepaniac, and Dana Messinger and Reinholdt lab members Whitney Martin, Candice Byers, and Anne Czechanski on a very story!

Our study describing the molecular basis of KIF18A’s accumulation at kMT ends is out in LSA

Heidi Malaby and Dominique Lessard (Berger Lab) use a combination of quantitative cell imaging and single molecule motility assays to show that KIF18A’s relatively long neck linker permits navigation of microtubules in the presence of microtubule-associated proteins and concentration of the motor at kinetochore microtubule (kMT) ends.  This work suggests that KIF18A’s ability to move around obstacles on microtubules is required for its chromosome alignment function. You can read the whole paper here in Life Science Alliance (open access).