This study describes an unexpected dependency of tumor cells that exhibit chromosome instability (CIN) on KIF18A for proliferation and survival.
The tumor cell screens in this study were greatly facilitated by a collaboration with Joe Clayton at BioTek Instruments. Funding from Susan G. Komen also brought together a fantastic team of scientists, clinicians, and patient advocates that provided key insights for the design of this work.
A press release summarizing the impact of the work and its connection to two recently published Nature papers can be found here.
Congratulations to Carolyn Marquis, who began this work as an undergraduate researcher in the lab, and all of the authors!