This study, led by Uri Ben-David at Tel Aviv University, uncovers genes that aneuploid tumor cells depend on more than near-diploid cells, including spindle assembly checkpoint components and KIF18A. This major collaborative effort involved six labs in five different countries.

Congrats to Stumpff Lab members Carolyn Marquis and Heidi Malaby, who co-authored this paper! A press release describing the work can be found here and a complementary co-published study from Neil Ganem’s lab on genes required for genome duplicated tumor cells can be found here.